Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. Running title: A novel small molecule targeting NF1-deficient MPNST cells

Supported by Prouty Norris Cotton Cancer Center Funds (YS) and NIH/NINDS R21NS060940 to YS and NR, NIH training grant T32-CA009658-18 YS, and by a Children’s Tumor Foundation Young Investigator Award to MDW. MDW is an Albert J. Ryan fellow. Address correspondence to Yolanda Sanchez Ph.D, Dartmouth Medical School, 7650 Remsen, Hanover, NH 03755, United States of America. Phone (603)650-1669 Fax (603)-650-1129 and to Nancy Ratner Ph.D, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Phone (513)-636-9469 Fax (513)-6361446. The authors declare no competing financial interest. Manuscript: 4999 words, 6 figures, 3 supplemental figures, 2 tables.